IRQ Coloring: Mitigating Interrupt-Generated Interference on ARM Multicore Platforms

Mixed-criticality systems, which consolidate workloads with different criticalities, must comply with stringent spatial and temporal isolation requirements imposed by safety-critical standards (e.g., ISO26262). This, per se, has proven to be a challenge with the advent of multicore platforms due to the inner interference created by multiple subsystems while disputing access to shared resources. With this work, we pioneer the concept of Interrupt (IRQ) coloring as a novel mechanism to minimize the interference created by co-existing interrupt-driven workloads. The main idea consists of selectively deactivating specific ("colored") interrupts if the QoS of critical workloads (e.g., Virtual Machines) drops below a well-defined threshold. The IRQ Coloring approach encompasses two artifacts, i.e., the IRQ Coloring Design-Time Tool (IRQ DTT) and the IRQ Coloring Run-Time Mechanism (IRQ RTM). In this paper, we focus on presenting the conceptual IRQ coloring design, describing the first prototype of the IRQ RTM on Bao hypervisor, and providing initial evidence about the effectiveness of the proposed approach on a synthetic use case

IRQ Coloring and the Subtle Art of Mitigating Interrupt-generated Interference

Integrating workloads with differing criticality levels presents a formidable challenge in achieving the stringent spatial and temporal isolation requirements imposed by safety-critical standards such as ISO26262. The shift towards high-performance multicore platforms has been posing increasing issues to the so-called mixed-criticality systems (MCS) due to the reciprocal interference created by consolidated subsystems vying for access to shared (microarchitectural) resources (e.g., caches, bus interconnect, memory controller). The research community has acknowledged all these challenges. Thus, several techniques, such as cache partitioning and memory throttling, have been proposed to mitigate such interference; however, these techniques have some drawbacks and limitations that impact performance, memory footprint, and availability. In this work, we look from a different perspective. Departing from the observation that safety-critical workloads are typically event- and thus interrupt-driven, we mask "colored" interrupts based on the \ac{QoS} assessment, providing fine-grain control to mitigate interference on critical workloads without entirely suspending non-critical workloads. We propose the so-called IRQ coloring technique. We implement and evaluate the IRQ Coloring on a reference high-performance multicore platform, i.e., Xilinx ZCU102. Results demonstrate negligible performance overhead, i.e., <1% for a 100 microseconds period, and reasonable throughput guarantees for medium-critical workloads. We argue that the IRQ coloring technique presents predictability and intermediate guarantees advantages compared to state-of-art mechanismsComment: 10 pages, 9 figures, 2 table

Towards a RISC-V Open Platform for Next-generation Automotive ECUs

The complexity of automotive systems is increasing quickly due to the integration of novel functionalities such as assisted or autonomous driving. However, increasing complexity poses considerable challenges to the automotive supply chain since the continuous addition of new hardware and network cabling is not considered tenable. The availability of modern heterogeneous multi-processor chips represents a unique opportunity to reduce vehicle costs by integrating multiple functionalities into fewer Electronic Control Units (ECUs). In addition, the recent improvements in open-hardware technology allow to further reduce costs by avoiding lock-in solutions. This paper presents a mixed-criticality multi-OS architecture for automotive ECUs based on open hardware and open-source technologies. Safety-critical functionalities are executed by an AUTOSAR OS running on a RISC-V processor, while the Linux OS executes more advanced functionalities on a multi-core ARM CPU. Besides presenting the implemented stack and the communication infrastructure, this paper provides a quantitative gap analysis between an HW/SW optimized version of the RISC-V processor and a COTS Arm Cortex-R in terms of real-time features, confirming that RISC-V is a valuable candidate for running AUTOSAR Classic stacks of next-generation automotive MCUs.Comment: 8 pages, 2023 12th Mediterranean Conference on Embedded Computing (MECO

Autophagy hijacking in PBMC From COVID-19 patients results in lymphopenia

Autophagy is a homeostatic process responsible for the self-digestion of intracellular components and antimicrobial defense by inducing the degradation of pathogens into autophagolysosomes. Recent findings suggest an involvement of this process in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the role of autophagy in the immunological mechanisms of coronavirus disease 2019 (COVID-19) pathogenesis remains largely unexplored. This study reveals the presence of autophagy defects in peripheral immune cells from COVID-19 patients. The impairment of the autophagy process resulted in a higher percentage of lymphocytes undergoing apoptosis in COVID-19 patients. Moreover, the inverse correlation between autophagy markers levels and peripheral lymphocyte counts in COVID-19 patients confirms how a defect in autophagy might contribute to lymphopenia, causing a reduction in the activation of viral defense. These results provided intriguing data that could help in understanding the cellular underlying mechanisms in COVID-19 infection, especially in severe forms

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p &lt; 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Security and Reconfigurability in Networked Embedded Systems

Nowadays, the convergence of communication, computing and control provides the ability to build large-scale, widely distributed, heterogeneous, pervasive, networked embedded systems, which not only have capabilities of sensing, but also of acting in and on the environment. Security in these systems is an open question that could prove to be a more difficult long-term problem than is today in desktop and enterprise computing. Given their interactive and pervasive nature, a security breach in embedded systems can result in severe privacy violations and physical side effects, including property damage, injury and even death. In order to be cost-effective and operational over time, embedded systems have to adapt to changing operating conditions by dynamically downloading software. Usually, such systems use wireless communication to simplify deployment and increase reconfigurability. It follows that an adversary can easily launch security logical attacks by downloading malicious software through the wireless medium. Furthermore, cost reasons often cause embedded devices to lack adequate physical/hardware support aimed at protection and tamper-resistance. This, together with the fact that devices can be deployed over unattended areas, implies that each embedded device is exposed to the risk of being compromised. In such scenario, compromised devices have to be logically removed from the network communication. However, removing the logical presence of compromised devices could not guarantee the usefulness and effectiveness of the network. Hence, the network has to be able to autonomously reconfigure itself by replacing compromised devices with new ones to cover all the geographical areas. With reference to such scenario, we focus on defining a security architecture for guaranteeing secure software reconfiguration and secure communication in networked embedded systems. Furthermore, we define a protocol for key distribution and revocation aimed at logically removing compromised devices from the network communication. Finally, we define a decentralized protocol to cope with the presence of compromised and damaged devices by using autonomous mobile devices. For our prototyping we consider a network composed of low-power, low-cost communication miniature computing sensors, such as Wireless Sensor Networks

An algorithm for reconnecting Wireless Sensor Network partitions

In a Wireless Sensor Network, sensor nodes may fail for several reasons and the network may split into two or more disconnected partitions. This may deteriorate or even nullify the usefulness and effectiveness of the network. Therefore, repairing partitions is a priority. In this paper we present a method to repair network partitions by using mobile nodes. By reasoning upon the degree of connectivity with neighbours, a mobile node finds the proper position where to stop in order to re-establish connectivity. Factors influencing the method performance are singled out and criteria for their selection are discussed. Simulations show that the proposed method is effective and efficient notwithstanding packet loss